CYP11B2 T-344C Gene Polymorphism and Atrial Fibrillation: A Meta-Analysis of 2,758 Subjects

نویسندگان

  • Yan-yan Li
  • Chuan-wei Zhou
  • Jian Xu
  • Yun Qian
  • Bei Wang
چکیده

BACKGROUND Aldosterone synthase (CYP11B2) T-344C gene polymorphism was found to be correlated with atrial fibrillation (AF) risk. However, the results of individual studies remain conflicting. OBJECTIVE AND METHODS A meta-analysis including 2,758 subjects from six individual studies was performed to explore the correlation between CYP11B2 T-344C gene polymorphisms and AF. The pooled odds ratios (ORs) and their corresponding 95% confidence intervals (95% CIs) were evaluated by the fixed- or random-effects model. RESULTS A significant relationship between CYP11B2 T-344C gene polymorphism and AF was found under allelic (OR: 1.26, 95% CI: 1.11-1.42, P = 0.0002), recessive (OR: 1.99, 95% CI: 1.26-3.14, P = 0.003), dominant (OR: 0.903, 95% CI: 0.820-0.994, P = 0.036), homozygous (OR: 1.356, 95% CI: 1.130-1.628, P = 0.001), and additive (OR: 1.153, 95% CI: 1.070-1.243, P = 1.0×10(-10)) genetic models. No significant association between CYP11B2 T-344C gene polymorphism and AF was found under the heterozygous genetic model (OR: 1.040, 95% CI: 0.956-1.131, P = 0.361). CONCLUSIONS A significant association was found between CYP11B2 T-344C gene polymorphism and AF risk. Individuals with the C allele of CYP11B2 T-344C gene polymorphism have higher risk for AF.

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عنوان ژورنال:

دوره 7  شماره 

صفحات  -

تاریخ انتشار 2012